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Objective: To retrospectively evaluate theefficacy of local uterine antibiotic and anti-inflammatory injections combinedwith cryotherapy for the treatment of severe Premenstrual Syndrome PMS andPremenstrual Dysphoric Disorder PMDD. To validate the hypothesis of a uterineinfectious-inflammatory etiology of PMS-PMDD. Methods: Clinical files of 161women sequentially treated from September 1995 to April 2005, were collectedfor study. A subset of 148 patients mean: 36.7 ± 7.8 years, range: 20.1 - 53.8years were eligible for statistical analysis. The ten most relevant PMSsymptoms, namely depression, irritability, anxiety, fatigue, headache, edema,breast tenderness, abdominal bloating, pelvic pain and dysmenorrhea, wereself-rated before and three menstrual cycles after treatment, using a 0 to 5scale. The treatment consisted of cervical stromal antibiotic-anti-inflammatoryinjections combined with intracervical cryotherapy. Scores were compared usingnon-parametric tests for matched samples. Results: Before treatment, meanseverity scores for the 10 symptoms were 3.97 ± 1.17, 4.26 ± 0.88, 3.41 ± 1.23,3.91 ± 0.94, 3.35 ± 1.71, 2.28 ± 1.69, 2.13 ± 1.63, 4.51 ± 0.63, 2.28 ± 1.30, and2.28 ± 1.88, respectively. Mean values after treatment were 0.54 ± 0.91, 0.51 ±0.91, 0.32 ± 0.70, 0.42 ± 0.74, 0.43 ± 0.96, 0.22 ± 0.53, 0.39 ± 0.73, 1.01 ±0.94, 0.28 ± 0.69, and 0.44 ± 0.92. All tests were statistically significant p< 0.01. Conclusion: Both PMS physical and psycho-affective symptoms respondto local anti-inflammatory and antibiotic treatment of the uterus, showing astable improvement after the treatment has ended. The results of this studysuggest that the clinical pattern of PMS can be explained as an inflammatorymediated response to uterine infectious or traumatic insults. Further evidenceis urgently needed in order to validate this innovative approach for widespreaduse in severe PMS- PMDD cases.


Premenstrual Syndrome, Premenstrual Dysphoric Disorder, Inflammatory Cytokines, Cervix Injections, Cervix Cryotherapy

Cite this paper

Lolas-Talhami, J. , Lafaja-Mazuecos, J. and Ferrández-Sempere, D. 2015 Is Premenstrual Syndrome a Uterine Inflammatory Disease? Retrospective Evaluation of an Etiologic Approach. Open Journal of Obstetrics and Gynecology, 5, 305-312. doi: 10.4236-ojog.2015.56044.

Autor: Jorge Lolas-Talhami1, Juana Lafaja-Mazuecos2, Diego Ferrández-Sempere3



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