Prevalence of Hypogonadotropic Hypogonadism in Type 2 Diabetes Male PatientsReportar como inadecuado

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Background: Erectile dysfunction is common in patients with diabetesmellitus. In addition, reduced testosterone itself is considered as a riskfactor for diabetes; therefore hypogonadism was studied in diabetes. Objective:This study was done to determine the prevalence of hypo- and hypergonadotropichypogonadism in the type 2 diabetes male patients in Mashhad in north-east of Iran.Methods: This study was done on type 2 diabetic men aged 40 - 60 years in theendocrine clinic, Endocrinology Research Center, Mashhad University of MedicalSciences, Iran. Fasting blood samples were collected at 8 am for measurement of fastingblood sugar FBS, HbA1C, total serum testosterone, FSH, Sex Hormone BindingGlobulin SHBG, LH, prolactin, thyroxin-stimulating hormone TSH, andimmediately was sent to laboratory. Results: Out of total 96 type 2 diabeticmales mean age of 51.4 ± 11.26 years, range of 40 - 60 years, 11 12.94%patients were excluded because of inadequate samples, insufficient informationand fulfillment of the exclusion criteria of the study. Hypogonadism based onTestosterone, Calculated free testosterone CFT, and boiavailable testosteroneBT were observed in 10 11.8%, 31 36.6%, and 30 35.3% of the patients, respectively.Libido was decreased in 55 64.7% of the patients. Based on the obtained SHBGvalues there were 7 8.2%, 52 61.2%, and 26 30.6% cases of low, normal andhigh values, respectively. According to TSH observed values there were 6 7.1%patients and 1 case of sub-clinical hypothyroidism and hyperthyroidism, respectively,and the rest 78 91.8% cases were euthyroid. Prolactin level was normal in allcases. Conclusion: Hypogonadotropic hypogonadism is common in type 2 diabeticmen, and whether its treatment is useful for erectile dysfunction or not, neededadditional investigation.


Type 2 Diabetes, Testosterone, Hypogonadism, Hypogonadotropic

Cite this paper

Afkhamizadeh, M. , Ghaderian, S. , Rajabian, R. and Aleali, A. 2015 Prevalence of Hypogonadotropic Hypogonadism in Type 2 Diabetes Male Patients. Open Journal of Endocrine and Metabolic Diseases, 5, 29-36. doi: 10.4236-ojemd.2015.53004.

Autor: Mozhgan Afkhamizadeh1, Seyed Bahman Ghaderian2*, Reza Rajabian1, Armaghan Moravej Aleali1



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