Dynamic Contrast-Enhanced MRI of Mouse Liver: A Feasibility Study Using a Dual-Input Two-Compartment Tracer Kinetic ModelReportar como inadecuado




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Dynamic contrast-enhanced magnetic resonance imaging DCE-MRI has been widely applied to evaluate microcirculatory parameters in clinical settings. However, pre-clinical studies involving DCE-MRI of small animals remain challenging with the requirement for high spatial and temporal resolution for quantitative tracer kinetic analysis. This study illustrates the feasibility of applying a high temporal resolution 2 s protocol for liver imaging in mice by analyzing the DCE-MRI datasets of mice liver with a dual-input two-compartment tracer kinetic model. Phantom studies were performed to validate the T1 estimates derived by the proposed protocol before applying it in mice studies. The DCE-MRI datasets of mice liver were amendable to tracer kinetic analysis using a dual-input two-compartment model. Estimated micro-circulatory parameters were consistent with liver physiology, indicating viability of applying the technique for pre-clinical drug developments.

KEYWORDS

DCE-MRI, Mouse, Liver Imaging, Preclinical Imaging

Cite this paper

Hartono, S. , Thng, C. , Chuang, K. , Hung, H. and Koh, T. 2015 Dynamic Contrast-Enhanced MRI of Mouse Liver: A Feasibility Study Using a Dual-Input Two-Compartment Tracer Kinetic Model. Journal of Biomedical Science and Engineering, 8, 90-97. doi: 10.4236-jbise.2015.82009.





Autor: Septian Hartono1,2*, Choon Hua Thng2, Kai Hsiang Chuang3, Huynh Hung4, Tong San Koh2

Fuente: http://www.scirp.org/



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