Short-Term Soy Isoflavone Intervention in Patients with Localized Prostate Cancer: A Randomized, Double-Blind, Placebo-Controlled TrialReportar como inadecuado




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Purpose

We describe the effects of soy isoflavone consumption on prostate specific antigen PSA, hormone levels, total cholesterol, and apoptosis in men with localized prostate cancer.

Methodology-Principal Findings

We conducted a double-blinded, randomized, placebo-controlled trial to examine the effect of soy isoflavone capsules 80 mg-d of total isoflavones, 51 mg-d aglucon units on serum and tissue biomarkers in patients with localized prostate cancer. Eighty-six men were randomized to treatment with isoflavones n = 42 or placebo n = 44 for up to six weeks prior to scheduled prostatectomy. We performed microarray analysis using a targeted cell cycle regulation and apoptosis gene chip GEArrayTM. Changes in serum total testosterone, free testosterone, total estrogen, estradiol, PSA, and total cholesterol were analyzed at baseline, mid-point, and at the time of radical prostatectomy. In this preliminary analysis, 12 genes involved in cell cycle control and 9 genes involved in apoptosis were down-regulated in the treatment tumor tissues versus the placebo control. Changes in serum total testosterone, free testosterone, total estrogen, estradiol, PSA, and total cholesterol in the isoflavone-treated group compared to men receiving placebo were not statistically significant.

Conclusions-Significance

These data suggest that short-term intake of soy isoflavones did not affect serum hormone levels, total cholesterol, or PSA.

Trial Registration

ClinicalTrials.gov NCT00255125



Autor: Jill M. Hamilton-Reeves , Snigdha Banerjee, Sushanta K. Banerjee, Jeffrey M. Holzbeierlein, J. Brantley Thrasher, Suman Kambhampa

Fuente: http://plos.srce.hr/



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