Retracted HIV Study Provides New Information about the Status of the in Vitro Inhibition of DNA Replication by Backbone MethylationReportar como inadecuado




Retracted HIV Study Provides New Information about the Status of the in Vitro Inhibition of DNA Replication by Backbone Methylation - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

In this publication attention is given to a retracted article in Science at the end of 1990 concerning the HIV-1 inhibition by a modified backbone DNA as the phosphatemethylated DNA. A disproportion in the presented data resulted in a faulty generalization of the biochemical characteristics of the phosphatemethylated DNA 18- and 20-nucleotides. In the confusion and the outside pressure a related study in Nucleic Acids Research on the in vitro dynamics of a regiospecific inhibition of DNA duplication with long 20- and 18-nucleotides and short 8-nucleotides phosphatemethylated DNA was completely ignored. A restoration will be given based on a comprehensive view demonstrating the unique molecular and conformational properties of phosphatemethylated DNA in their biochemistry towards natural DNA and RNA HIV-1 RNA loops.

KEYWORDS

Phosphatemethylated DNA, Conformational Study, HIV-1, E. coli pab B Gene, in Vitro Inhibition of DNA Replication

Cite this paper

Buck, H. 2015 Retracted HIV Study Provides New Information about the Status of the in Vitro Inhibition of DNA Replication by Backbone Methylation. Journal of Biophysical Chemistry, 6, 29-34. doi: 10.4236-jbpc.2015.61003.





Autor: Henk M. Buck

Fuente: http://www.scirp.org/



DESCARGAR PDF




Documentos relacionados