Systemic Inflammatory Markers and Disease Severity in Chronic Obstructive Pulmonary Disease—The Effect of Acute Exercise and Pulmonary RehabilitationReportar como inadecuado




Systemic Inflammatory Markers and Disease Severity in Chronic Obstructive Pulmonary Disease—The Effect of Acute Exercise and Pulmonary Rehabilitation - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Background: Decreased physical capacity and increased systemic inflammatory response are frequently observed in patients with chronic obstructive pulmonary disease COPD. The relationship between the inflammatory response and disease severity and the immunological response to exercise were addressed in COPD. Objective: The first objective was to identify systemic biomarkers and their relationship with COPD severity. The second objective was to examine the effect of both acute exercise and pulmonary rehabilitation on these biomarkers. Methods: Forty subjects participated in the study. Thirty-two patients with moderate or severe COPD and 8 healthy non-smokers completed the study. Spirometry was preformed. Physical capacity was determined by a progressive symptom-limited cycle ergo meter incremental test. Blood samples were analyzed for C-reactive protein CRP, pro-inflammatory cytokines IL-6, TNF-α, pro-fibrotic cytokines TGF-β and oxidative burst in circulating leukocytes before and after exercise, and before and after pulmonary rehabilitation. Results: IL-6, CRP, WCC and TGF-β were higher in COPD p < 0.05 than eight healthy controls. WCC, IL-6, TNF-α, CRP and TGF-β were negatively related to forced expiratory volume in 1 s FEV1 r = 0.4054, 0.3221, 0.1528, 0.1846 and 0.1187, respectively. Acute exercise increased circulating leucocytes and oxidative stress in both groups p = 0.000, 0.0049 respectively, while IL-6 was increased in COPD group p = 0.0115 and circulating TNF-α in healthy control p = 0.0369. Pulmonary rehabilitation didn’t modify the levels of inflammatory mediators. Conclusions: Reduced lung function is associated with increased levels of systemic inflammatory markers and acute exercise can further increase this inflammatory response. However pulmonary rehabilitation is unlikely to exacerbate systemic inflammation in COPD.

KEYWORDS

Systemic Inflammation, COPD, Oxidative Stress, Pulmonary Rehabilitation

Cite this paper

El Gammal, A. , O’Farrell, R. , O’Mahony, L. , Shanahan, F. , Killian, K. and O’Connor, T. 2015 Systemic Inflammatory Markers and Disease Severity in Chronic Obstructive Pulmonary Disease—The Effect of Acute Exercise and Pulmonary Rehabilitation. Open Journal of Respiratory Diseases, 5, 19-31. doi: 10.4236-ojrd.2015.51003.





Autor: Amani I. El Gammal1*, Rob O’Farrell1, Liam O’Mahony3, Fergus Shanahan2, Kieran Killian4, Terence M. O’Connor1

Fuente: http://www.scirp.org/



DESCARGAR PDF




Documentos relacionados