Utilisation de traceurs radioactifs pour lévaluation du recrutement des leucocytes et des échanges vasculaires au niveau dorganes $in~vivo$. Description dune méthode et discussion des problèmes dinterprétation sur quelques eReportar como inadecuado




Utilisation de traceurs radioactifs pour lévaluation du recrutement des leucocytes et des échanges vasculaires au niveau dorganes $in~vivo$. Description dune méthode et discussion des problèmes dinterprétation sur quelques e - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.



Abstract : An experimental method using simultaneously different γ emiter tracers was developed to evaluate inflammation in vivo. Experiments were performed on the anaesthetized guinea-pig to test pulmonary effects of inflammatory agents. Red blood cells, albumin and inflammatory cells platelets or leucocytes radiolabelled with 99m technetium, 131 iodine and 111 indium respectively were injected i.v. Their radioactivities were measured on a pulmonary region by external detection and on blood samples in a well type counter. From these measurements variations of the lung contents in red blood cells, extravascular albumin and non circulating leucocytes during inflammatory stimulation were evaluated. These parameters axe indexes of blood perfusion, vascular exchanges and leucocyte sequestration respectively. Fiability of the method and meaning of the parameters evaluated are discussed.





Autor: M. Bureau

Fuente: https://hal.archives-ouvertes.fr/



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