Diffusion Tensor Magnetic Resonance Imaging of the Brain in APP Transgenic Mice: A Cohort StudyReportar como inadecuado




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Introduction

Fast in-vivo high resolution diffusion tensor imaging DTI of the mouse brain has recently been shown to enable cohort studies by the combination of appropriate pulse sequences and cryogenically cooled resonators CCR. The objective of this study was to apply this DTI approach at the group level to β-amyloid precursor protein APP transgenic mice.

Methods

Twelve mice 5 wild type, 7 APP transgenic tg2576 underwent DTI examination at 1562×250 µm3 spatial resolution with a CCR at ultrahigh field 11.7 T. Diffusion images were acquired along 30 gradient directions plus 5 references without diffusion encoding with a total acquisition time of 35 minutes. Fractional anisotropy FA maps were statistically compared by whole brain-based spatial statistics WBSS at the group level vs. wild type controls.

Results

FA-map comparison showed characteristic regional patterns of differences between the groups with localizations associated with Alzheimer’s disease in humans, such as the hippocampus, the entorhinal cortex, and the caudoputamen.

Conclusion

In this proof-of-principle study, regions associated with amyloid-β deposition could be identified by WBSS of FA maps in APP transgenic mice vs. wild type mice. Thus, DTI in the mouse brain acquired at 11.7 T by use of a CCR was demonstrated to be feasible for cohort studies.



Autor: Hans-Peter Müller , Jan Kassubek , Ina Vernikouskaya, Albert C. Ludolph, Detlef Stiller , Volker Rasche

Fuente: http://plos.srce.hr/



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