ESR1 Gene Polymorphisms and Prostate Cancer Risk: A HuGE Review and Meta-AnalysisReportar como inadecuado




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Background

Many published data on the association between single nucleotide polymorphisms SNPs in the ESR1 gene and prostate cancer susceptibility are inconclusive. The aim of this Human Genome Epidemiology HuGE review and meta-analysis is to derive a more precise estimation of this relationship.

Methods

A literature search of PubMed, Embase, Web of Science and Chinese Biomedical CBM databases was conducted from their inception through July 1st, 2012. Crude odds ratios ORs with 95% confidence intervals CIs were calculated to assess the strength of association.

Results

Twelve case-control studies were included with a total 2,165 prostate cancer cases and 3,361 healthy controls. When all the eligible studies were pooled into the meta-analysis, ESR1 PvuII C>T and XbaI A>G polymorphisms showed no association with the risk of prostate cancer. However, in the stratified analyses based on ethnicity and country, the results indicated that ESR1 PvuII C>T polymorphism was significantly associated with increased risk of prostate cancer among Asian populations, especially among Indian population; while ESR1 XbaI A>G polymorphism may significantly increase the risk of prostate cancer among American population. Furthermore, we also performed a pooled analysis for all eligible case-control studies to explore the role of codon 10 T>C, codon 325 C>G, codon 594 G>A and +261G>C polymorphisms in prostate cancer risk. Nevertheless, no significant associations between these polymorphisms and the risk of prostate cancer were observed.

Conclusion

Results from the current meta-analysis indicate that ESR1 PvuII C>T polymorphism may be a risk factor for prostate cancer among Asian populations, especially among Indian population; while ESR1 XbaI A>G polymorphism may increase the risk of prostate cancer among American population.



Autor: Yu-Mei Wang , Zu-Wang Liu, Jing-Bo Guo, Xiao-Fang Wang, Xin-Xin Zhao, Xuan Zheng

Fuente: http://plos.srce.hr/



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