Expression Imbalance of Cholinergic M2 and M3 Receptors Contributes to the Motility Reduction of the Small Intestine in Spleen Qi DeficiencyReportar como inadecuado




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Objective: To study roles of cholinergic M2 and M3 receptors in the motility reduction of small intestine SI in spleen qi deficiency. Methods: 16 male SD rats were randomly divided in the control group and spleen qi deficiency group model group—8 rats each group; spleen qi deficiency model of the improper diet and overfatigue was established; the SI propelling rate SIPR was used to evaluate the SI motility; ELISA was used to measure concentrations of acetylcholine ACh, cyclic adenosine monophosphate cAMP and protein kinase A PKA in the SI tissue; immohistochemistry was employed to detect expressions of cholinergic M2 and M3 receptors. Results: Compared with those in the control group, SIPR was reduced; expression of M2 receptors was increased; and expression of M3 receptors and concentrations of cAMP and PKA were decreased, significantly, in the model group. Conclusions: Expression imbalance of cholinergic M2 and M3 receptors might contribute to the motility reduction of the SI in spleen qi deficiency.

KEYWORDS

Spleen Qi Deficiency, Small Intestine Motility, M2 Receptor, M3 Receptor

Cite this paper

Zhao, F. , Liu, X. , Liu, W. , Cai, J. , Wang, L. , Yu, H. , Wang, L. , Zhang, L. , Wang, D. and Shan, D. 2014 Expression Imbalance of Cholinergic M2 and M3 Receptors Contributes to the Motility Reduction of the Small Intestine in Spleen Qi Deficiency. Chinese Medicine, 5, 165-169. doi: 10.4236-cm.2014.54020.





Autor: Fan Zhao, Xudong Liu, Wenjun Liu, Jiyan Cai, Lingzhi Wang, Huaxin Yu, Lu Wang, Lide Zhang, Deshan Wang, Dehong Shan*

Fuente: http://www.scirp.org/



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