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Cellulases andhemicellulases are the main industrial sources from different microorganisms used to depolymerise plant biomass to simple sugars that are converted tochemical intermediates and biofuels, such as ethanol. Cellulases are formedadaptively, and several positive xyr1,Ace2, HAP2-3-5 and negative Ace1, Cre1 components involved in thisregulation are now known. In this review, we summarise current knowledge abouthow cellulase biosynthesis is regulated, and outline recent approaches andsuitable strategies for facilitating the targeted improvement of cellulaseproduction by genetic engineering. Trichodermareesei is the preferred organism for producing industrial cellulases.However, a more efficient heterologous expression system for enzymes fromdifferent organism is needed to further improve its cellulase mixture. Inaddition those optimizations of the promoter and linker for hybrid genes candramatically improve the efficiency of heterologous expression of cellulasegenes.


Cellulase, Regulation, Transcription, Promoter, Review

Cite this paper

Ali, N. , Athar, M. , Khan, Y. , Idrees, M. and Ahmad, D. 2014 Regulation and Improvement of Cellulase Production: Recent Advances. Natural Resources, 5, 857-863. doi: 10.4236-nr.2014.514073.

Autor: Nasir Ali1*, Muhammad Ammar Athar1, Yasir Hayat Khan1, Muhammad Idrees2, Dawood Ahmad3



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