Association between Adverse Childhood Experiences and Diagnosis of CancerReportar como inadecuado

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Adverse childhood experiences ACEs are linked to multiple adverse health outcomes. This study examined the association between ACEs and cancer diagnosis.


Data from the 2010 Behavioral Risk Factor Surveillance System BRFSS survey were used. The BRFSS is the largest ongoing telephone health survey, conducted in all US states, the District of Columbia, Puerto Rico, Guam and the U.S. Virgin Islands, and provides data on a variety of health issues among the non-institutionalized adult population. Principal component analysis PCA was used to derive components for ACEs. Multivariable logistic regression models were used to provide adjusted odds ratios OR and 95% confidence intervals CI for the association between ACE components and overall, childhood and adulthood cancer, adjusting for confounders such as age, gender, race-ethnicity, income, educational status, marital status, and insurance status.


Approximately 62% of respondents reported being exposed to ACEs and about one in ten respondents reported ever having been diagnosed with cancer. Component 1, which had the sexual abuse variables with the highest weights, was significantly associated with adulthood cancer adjusted OR: 1.21; 95% CI: 1.03–1.43.


The association between ACEs and adulthood cancer may be attributable to disease progression through association of ACEs with risk factors for other chronic diseases. More research should focus on the impact of sexual abuse ACEs and adverse health outcomes.

Autor: Monique J. Brown , Leroy R. Thacker, Steven A. Cohen



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