Melatonin Avoids Anatomofunctional Changes Associated to Aging in a Rat ModelReportar como inadecuado




Melatonin Avoids Anatomofunctional Changes Associated to Aging in a Rat Model - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Melatonin is a hormone synthesized and released primarily by the pineal gland. Its secretion fol-lows a circadian rhythm with a peak overnight. Its secretion is initiated approximately to the three months of age and continues to rise during the childhood. Previous to the puberty there is a de-crease of melatonin secretion that continues until the old age. Melatonin has effects in the body and acts through at least four mechanisms: membrane receptors, orphan nuclear receptors, calmodulin and free radicals. It has been suggested that aging can be a consequence of the oxidation of cells that eventually become vulnerable to injury and die. This work reviews the antioxidant effects of melatonin in a rodent model, on the formation of free radicals, on the MAP2 protein expression and on the electrophysiology of the hippocampus at different ages. The results indicate that melatonin maintains in a -best- state to the experimental animals compared to controls. It suggests the use of melatonin as a therapy to prevent or delay the aging effects on the cells.

KEYWORDS

Rat, Melatonin, Hippocampus, Antioxidant, Aging

Cite this paper

Gómez, B. , Reyes-Vázquez, C. and Velázquez-Paniagua, M. 2014 Melatonin Avoids Anatomofunctional Changes Associated to Aging in a Rat Model. Advances in Aging Research, 3, 318-325. doi: 10.4236-aar.2014.34041.





Autor: Bertha Prieto Gómez*, Cruz Reyes-Vázquez, Mireya Velázquez-Paniagua

Fuente: http://www.scirp.org/



DESCARGAR PDF




Documentos relacionados