Routine CSF Analysis in Coccidioidomycosis Is Not RequiredReport as inadecuate

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Although routinely done, there has been no evaluation of the utility of performing routine cerebrospinal fluid CSF examination in patients with active coccidioidomycosis and high complement fixation IgG antibody titers or other risk factors for disseminated infection. In our review 100% of patients diagnosed with coccidioidal meningitis had at least one sign or symptom consistent with infection of the central nervous system, headache was present in 100% of those with meningitis, while no patients without signs-symptoms of CNS infection were found to have coccidioidal meningitis, irrespective of antibody titers or other risk factors. Thus routine lumbar puncture may be unnecessary for patients with coccidioidomycosis who lack suggestive clinical symptoms.

Author: George Thompson III , Sharon Wang, Robert Bercovitch, Michael Bolaris, Dane Van Den Akker, Sandra Taylor, Rodrigo Lopez, Antonio



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