The pharmacokinetics of ceftazidime in E. coli lipopolysaccharide induced febrile buffalo calves.Reportar como inadecuado

The pharmacokinetics of ceftazidime in E. coli lipopolysaccharide induced febrile buffalo calves. - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Veterinary Archives, Vol.82 No.6 December 2012. -

The pharmacokinetic properties of ceftazidime, a third generation cephalosporin, were investigated in experimentally induced febrile buffalo calves n=5 after a single intravenous administration at a dose rate of 10 mg-kg body weight. The fever was induced by a single-repeated intravenous injection of E. coli lipopolysaccaride 1 μg-kg. Ceftazidime concentrations in the plasma and urine were determined by microbiological assay. Ceftazidime disposition was best fitted by a bi-compartmental open model with first-order elimination. At 2.5 min, the concentration of ceftazidime in the plasma of the febrile animals was 152.3 ± 6.77 μg-mL and the drug was detected up to 14 h. The elimination half-life and volume of distribution were 3.73 ± 0.42 h and 0.26 ± 0.05 L-kg, respectively. The distribution half-life, AUC and total body clearance ClB were 0.24 ± 0.03 h, 217.3 ± 23.4 μg-mL.h and 47.9 ± 4.57 mL-kg-h, respectively. Urinary excretion of ceftazidime was less than 28 percent after 32 h of administration of the drug in the febrile animals. An efficacy predictor, measured as the time over which the active drug exceeds the bacteria minimum inhibitory concentration T>MIC, was calculated. T>MIC was 73% of the recommended dosing interval 8h for bacteria with a MIC90≤4 μg-mL.

buffalo calf; ceftazidime; dosage regimen; fever; pharmacokinetics

Autor: Suresh K. Sharma - ; Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterina



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