Aberrant Functional Organization within and between Resting-State Networks in ADReportar como inadecuado

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Altered functional characteristics have been reported in amnestic mild cognitive impairment aMCI and Alzheimer’s disease AD; nonetheless, comprehensive analyses of the resting-state networks RSNs are rare. This study combined multiple imaging modalities to investigate the functional and structural changes within each RSN and between RSNs in aMCI-AD patients. Eight RSNs were identified from functional MRI data from 35 AD, 18 aMCI and 21 normal control subjects using independent component analysis. We compared functional connectivity FC within each RSN and found decreased FC in the several cognitive-related RSNs in AD, including the bilateral precuneus of the precuneus network, the posterior cingulate cortex and left precuneus of the posterior default mode network DMN, and the left superior parietal lobule of the left frontoparietal network LFP. We further compared the grey matter volumes and amplitudes of low-frequency fluctuations of these regions and found decreases in these measures in AD. Importantly, we found decreased inter-network connectivity between the visual network and the LFP and between the anterior and posterior DMNs in AD. All indices in aMCI patients were numerically between those of controls and AD patients. These results suggest that the brain networks supporting complex cognitive processes are specifically and progressively impaired over the course of AD, and the FC impairments are present not only within networks but also between networks.

Autor: Jinyu Song, Wen Qin, Yong Liu, Yunyun Duan, Jieqiong Liu, Xiaoxi He, Kuncheng Li, Xinqing Zhang , Tianzi Jiang , Chunshui Yu

Fuente: http://plos.srce.hr/


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