Total and Carboxylated Osteocalcin Associate with Insulin Levels in Young Adults Born with Normal or Very Low Birth WeightReportar como inadecuado




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Objective

Osteocalcin OC, a bone-derived protein, has been implicated in the regulation of glucose and energy metabolism. Young adults born with very low birth weight VLBW have altered glucose regulation and lower bone mineral density BMD compared with those born at term. The aim of this study was to explore the association between bone and glucose metabolism in healthy young adults born prematurely or at term.

Methods

The cohort of this cross-sectional study comprised 332 non-diabetic young adults age 18 to 27 years born either preterm with VLBW n = 163 or at term n = 169. OC, carboxylated osteocalcin cOC and markers of glucose metabolism were measured at fasting and after a 75-g oral glucose tolerance test OGTT.

Results

VLBW adults were shorter, had lower BMD p<0.001 and higher fasting OC p = 0.027 and cOC p = 0.005 than term-born subjects. They also had higher 2-hour insulin p = 0.001 and glucose p = 0.037 concentrations. OGTT induced a significant reduction in OC p<0.001, similar in both groups. OC reduction was not associated with OGTT-induced increases in insulin p = 0.54. However, fasting total OC and cOC correlated negatively with fasting insulin after adjustment for age, gender, BMD and VLBW status r = −0.182, p = 0.009 and r = −0.283, p<0.001, respectively.

Conclusion

Adults born with VLBW have higher OC and cOC than their peers born at term. This may in part reflect the mechanisms that underlie their lower BMD and decreased insulin sensitivity. Serum OC appears to be negatively associated with long-term glucose regulation whereas acute changes during OGTT may be mediated via other mechanisms.



Autor: Päivi M. Paldánius , Kaisa K. Ivaska , Petteri Hovi, Sture Andersson, Johan G. Eriksson, Kalervo Väänänen, Eero Kajantie, Ou

Fuente: http://plos.srce.hr/



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