Analyses of the Survival Time and the Influencing Factors of Chinese Patients with Prion Diseases Based on the Surveillance Data from 2008–2011Reportar como inadecuado




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Background

Prion diseases are kinds of progressive, incurable neurodegenerative disorders. So far, survival time of the patients with these diseases in China is unclear.

Methods

Based upon the surveillance data from Chinese Creutzfeldt-Jakob disease CJD surveillance network from January 2008 to December 2011, a retrospective follow-up survey was performed. The survival times of Chinese patients with prion diseases and the possible influencing factors were analyzed.

Results

Median survival time of 121 deceased patients was 7.1 months, while those for sporadic CJD sCJD, familial CJD fCJD and fatal familial insomnia FFI cases were 6.1, 3.1 and 8.2 months, respectively. 74.0% of sCJD patients, 100% of fCJD cases and 91.7% FFI cases died within one year. The general socio-demographic factors, abnormalities in clinical examinations, clinical manifestations, and social factors did not significantly influence the survival times of Chinese prion patients.

Conclusions

Survival time of Chinese patients with prion diseases was comparable with that of many Western countries, but obviously shorter than that of Japan. Patients with acute onset and rapid progression had significantly short survival times.



Autor: Cao Chen , Ji-Chun Wang , Qi Shi, Wei Zhou, Xiao-Mei Zhang, Jin Zhang, Chan Tian, Chen Gao, Xiao-Ping Dong

Fuente: http://plos.srce.hr/



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