Identification of a Breast Cancer Susceptibility Locus at 4q31.22 Using a Genome-Wide Association Study ParadigmReportar como inadecuado




Identification of a Breast Cancer Susceptibility Locus at 4q31.22 Using a Genome-Wide Association Study Paradigm - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

More than 40 single nucleotide polymorphisms SNPs for breast cancer susceptibility were identified by genome-wide association studies GWASs. However, additional SNPs likely contribute to breast cancer susceptibility and overall genetic risk, prompting this investigation for additional variants. Six putative breast cancer susceptibility SNPs identified in a two-stage GWAS that we reported earlier were replicated in a follow-up stage 3 study using an independent set of breast cancer cases and controls from Canada, with an overall cumulative sample size of 7,219 subjects across all three stages. The study design also encompassed the 11 variants from GWASs previously reported by various consortia between the years 2007–2009 to i enable comparisons of effect sizes, and ii identify putative prognostic variants across studies. All SNP associations reported with breast cancer were also adjusted for body mass index BMI. We report a strong association with 4q31.22-rs1429142 combined per allele odds ratio and 95% confidence interval = 1.28 1.17–1.41 and Pcombined = 1.5×10−7, when adjusted for BMI. Ten of the 11 breast cancer susceptibility loci reported by consortia also showed associations in our predominantly Caucasian study population, and the associations were independent of BMI; four FGFR2 SNPs and TNRC9-rs3803662 were among the most notable associations. Since the original report by Garcia-Closas et al. 2008, this is the second study to confirm the association of 8q24.21-rs13281615 with breast cancer outcomes.



Autor: Yadav Sapkota, Yutaka Yasui, Raymond Lai, Malinee Sridharan, Paula J. Robson, Carol E. Cass, John R. Mackey, Sambasivarao Damaraj

Fuente: http://plos.srce.hr/



DESCARGAR PDF




Documentos relacionados