Combined Use of Waist and Hip Circumference to Identify Abdominally Obese HIV-Infected Patients at Increased Health RiskReportar como inadecuado




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Objectives

To determine whether for a given waist circumference WC, a larger hip circumference HC was associated with a reduced risk of insulin resistance, type 2 diabetes T2D, hypertension and cardiovascular disease CVD in HIV-infected patients. A second objective was to determine whether, for a given WC, the addition of HC improved upon estimates of abdominal adiposity, in particular visceral adipose tissue VAT, compared to those obtained by WC alone.

Methods

HIV-infected men N = 1481 and women N = 841 were recruited between 2005 and 2009. WC and HC were obtained using standard techniques and abdominal adiposity was measured using computed tomography.

Results

After control for WC and covariates, HC was negatively associated with risk of insulin resistance p<0.05 and T2D Men: OR = 0.91 95% CI: 0.86–0.96; Women: OR = 0.91 95% CI: 0.84–0.98. For a given WC, HC was also negatively associated with a lower risk of hypertension p<0.05 and CVD OR = 0.94 95% CI: 0.88–0.99 in men, but not women. Although HC was negatively associated with VAT in men and women after control for WC p<0.05, the addition of HC did not substantially improve upon the prediction of VAT compared to WC alone.

Conclusions

The identification of HIV-infected individuals at increased health risk by WC alone is substantially improved by the addition of HC. Estimates of visceral adipose tissue by WC are not substantially improved by the addition of HC and thus variation in visceral adiposity may not be the conduit by which HC identifies increased health risk.



Autor: Trevor O’Neill, Giovanni Guaraldi, Gabriella Orlando, Federica Carli, Elisa Garlassi, Stefano Zona, Jean-Pierre Després, Rober

Fuente: http://plos.srce.hr/



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