The Role of Coconut Water on Nicotine-Induced Reproductive Dysfunction in Experimental Male Rat ModelReportar como inadecuado




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The coconut wateris the most nutritious wholesome beverage in all coconut producing countries.Folk medicine describes the use of coconut water to reduce toxic effects ofnicotine and alcohol in reproductive function in men, but its direct evidenceis lacking. The aim of this study was to investigate the effects of tender andmature coconut water consumption on nicotine induced changes in sperm quality,spermatogenic cell density, activity of testicular marker enzymes for spermatogenesisand testosterone level of male healthy rats. Male Sprague Dawley rats weretreated with tender and mature coconut water intragastrically and nicotinesubcutaneously for 15 days. The findings indicated that the coconut water supplementationimproves epididymal spermatogenic cell density p ≤ 0.05, sperm motility andmorphology which were altered by nicotine. The activity of acid phosphatase andalkaline phosphatase was increased p ≤ 0.05, which indicates that treatmentwith coconut water provides significant protection of germinal epithelium fromnicotine toxicity. Coconut water also shows a significant increase p ≤ 0.05in testosterone levels in nicotine treated rats. Coconut water ameliorates thereproductive toxicity caused by nicotine due to presence on nutrients L-arginine,ascorbic acid, minerals like calcium and magnesium.



KEYWORDS

Rat Sperm, Testosterone, Nicotine, Coconut Water, L-Arginine

Cite this paper

Nair, S. and Rajamohan, T. 2014 The Role of Coconut Water on Nicotine-Induced Reproductive Dysfunction in Experimental Male Rat Model. Food and Nutrition Sciences, 5, 1121-1130. doi: 10.4236-fns.2014.512122.





Autor: Sandhya Vijayam Gopalakrishnan Nair, Thankappan Rajamohan

Fuente: http://www.scirp.org/



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