Risk Factors of Superimposed Preeclampsia in Women with Essential Chronic Hypertension Treated before PregnancyReportar como inadecuado




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Objective

To determine risk factors of superimposed preeclampsia in women with essential chronic hypertension receiving antihypertensive therapy prior to conception.

Methods

A retrospective study of 211 patients that analyzed risk factors of superimposed preeclampsia at first prenatal visit.
Variables with a p<.1 at univariate analysis were included in a logistic regression analysis.
P<.05 was considered as significant.

Results

Superimposed preeclampsia occurred in 49 23.2% women.
In logistic regression analysis, previous preeclampsia OR: 4.05 1.61–10.16, and mean arterial blood pressure of 95 mmHg or higher OR: 4.60 1.94–10.93 were associated with increased risk of superimposed preeclampsia.
When both variables were present, sensitivity, specificity, positive predictive value, negative predictive value, and likelihood ratio for superimposed preeclampsia were 43%, 94%, 70%, 85%, and 7.71 95% CI: 3.20–18.57, respectively.

Conclusion

In essential chronic hypertensive women, previous preeclampsia and mean arterial blood pressure of 95 mmHg or higher are associated with increased risks of superimposed preeclampsia.



Autor: Edouard Lecarpentier, Vassilis Tsatsaris, François Goffinet, Dominique Cabrol, Baha Sibai, Bassam Haddad

Fuente: http://plos.srce.hr/





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