Rapid and Sensitive CZE Method for Quality Control Analysis of Pharmaceuticals Containing Pseudoephedrine, Triprolidine and ParacetamolReportar como inadecuado




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A rapid and sensitive CZE Capillary Zone Electrophoresis method for pharmaceutical analysis was developed and fully validated.
The active compounds: Pseudoephedrine hydrochloride PSE, Triprolidine hydrochloride TRI and Paracetamol PAR were separated and quantitatively determined using the tris-borate 30 mM buffer at pH = 9.0 as a Background Electrolyte BGE.
The electrophoretic separation was carried out at 25 kV in an unmodified fused silica capillary of I.D.
= 50 μm with a -bubble-cell- for UV detection at 210 nm and 25°C.
The separation was reached in about 3 min.
After calibration the method was applied for analysis of three commercially available pharmaceutical preparations.
The repeatability RSD% of migration time tm was ranging between 0.47% and 0.90% and of peak areas A between 0.63% and 3.64%.
The Limit of Detection LOD values was of 0.19 μg-mL, 0.31 μg-mL and 0.08 μg-mL for respectively PSE, TRI and PAR.
The results obtained in this study showed that the proposed method was useful in routinely analysis of pharmaceuticals.

KEYWORDS

Capillary Zone Electrophoresis, Triprolidine, Pseudoephedrine, Paracetamol, Pharmaceutical Analysis, Validation

Cite this paper

Di Berardino, S.
and Jasionowska, R.
2014 Rapid and Sensitive CZE Method for Quality Control Analysis of Pharmaceuticals Containing Pseudoephedrine, Triprolidine and Paracetamol.
American Journal of Analytical Chemistry, 5, 613-619.
doi: 10.4236-ajac.2014.59069.






Autor: Sonia Di Berardino, Renata Jasionowska

Fuente: http://www.scirp.org/





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