Resveratrol Reverses the Impaired Vasodilation Observed in 2K-1C Hypertension through Endothelial Function ImprovementReportar como inadecuado




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Background: The production of endothelial-derived factors induces either vasoconstriction or vasodilation; nitric oxide NO is the most distinguished relaxing factor. Endothelial dysfunction is associated with hypertension. The partial loss in the NO-promoted vasodilation is due to its decreased bioavailability and-or to an activity reduction of endothelium NO synthase eNOS. Reactive oxygen species ROS, present in oxidative stress, seize NO and diminish its bioavailability. Transresveratrol RESV has been proved to increase NO and eNOS levels. Thus, RESV could be capable of improving NO dependent vascular relaxation on aortic rings isolated from treated 2K-1C animals through ROS damage reduction. Aim: Evaluate the effects of RESV treatment on the relaxation of aortic rings isolated from treated 2K-1C rats while focusing on the effects of the treatment on systolic blood pressure. Methods: Male Wistar rats 180 g were grouped: two 2K-1C and two Sham groups, one of each was treated with RESV 20 mg-kg, gavage dissolved in Tween 80 and one of each was treated with water plus Tween 80 control for six weeks. The rats had their systolic blood pressure SBP measured before and after the treatments. Vascular reactivity studies were conducted in order to observe and compare acetylcholine ACh-induced relaxations in the presence and absence of the NOS inhibitor L-NAME 10-4 mol-L. Results: SBP for 2K-1C was significantly reduced in the treated group 179.13 ± 4.90 mmHg, n = 23 when compared to the untreated group 196.66 ± 6.06 mmHg, n = 15, p < 0.01. The maximum relaxation of aortic rings isolated from the 2K-1C treated group showed a higher efficacy 116.63% ± 1.72%, n = 12 than that from the untreated group 85.97% ± 0.69%, n = 6, p < 0.001; L-NAME exposure was responsible for a significant decrease in each group’s maximum relaxation efficacy. Conclusions: SBP reduction observed after RESV treatment in rat renal hypertension could be due to the reestablishment of vascular relaxation depend of NO.

KEYWORDS

Resveratrol, Renal Hypertension, Nitric Oxide NO, Vasodilation, Reactive Oxygen Species ROS, Endothelium, Vascular Smooth Muscle

Cite this paper

Pereira, B. , Scalabrini, A. , Marinho, T. , Antonietto, C. and Restini, C. 2014 Resveratrol Reverses the Impaired Vasodilation Observed in 2K-1C Hypertension through Endothelial Function Improvement. Open Journal of Medicinal Chemistry, 4, 61-69. doi: 10.4236-ojmc.2014.42004.





Autor: B. F. M. Pereira, A. C. Scalabrini, T. S. Marinho, C. R. K. Antonietto, C. B. A. Restini

Fuente: http://www.scirp.org/



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