Latent Tuberculosis Infection - Rad Croatian Academy of Sciences and Arts. Medical science : Medical Sciences, No.511=37 May 2012.Reportar como inadecuado




Latent Tuberculosis Infection - Rad Croatian Academy of Sciences and Arts. Medical science : Medical Sciences, No.511=37 May 2012. - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Rad Croatian Academy of Sciences and Arts. Medical science : Medical Sciences, No.511=37 May 2012. -

Latent tuberculosis infection LTBI is a subclinical infection with Mycobacterium M. tuberculosis. Children and immunosuppressed individuals due to pathologic conditions or therapeutic procedures are at a high risk of reactivation of LTBI to active disease compared to general population and require timely identification. The diagnosis of LTBI is based on the measurement an adaptive immune response against M. tuberculosis. The use of tuberculin skin test TST has been associated with a number of interfering factors that cause false-positive or false-negative test results. The new ex vivo whole blood tests determining interferon-gamma IFN-γ released from T-lymphocytes interferon-gamma release assays, IGRAs upon stimulation with M. tuberculosis specific antigens. The introduction of IGRAs to routine clinical practice has improved the diagnosis of LTBI, but recommendations and guidelines for the diagnosis of LTBI are not consistent between different European countries. Therefore, European centre for disease prevention and control developed guidance document based on the up-to-date scientific evidence. Novel concepts of IGRAs and new studies should be designed so as to provide answers to all open questions.

interferon-gamma release assay; latent tuberculosis infection; tuberculin skin test



Autor: Renata Zrinski Topić - ; Department of Clinical Laboratory Diagnosis, Srebrnjak Children’s Hospital, Zagreb, Croatia

Fuente: http://hrcak.srce.hr/



DESCARGAR PDF




Documentos relacionados