A Readily Applicable Strategy to Convert Peptides to Peptoid-based TherapeuticsReportar como inadecuado

A Readily Applicable Strategy to Convert Peptides to Peptoid-based Therapeutics - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Incorporation of unnatural amino acids and peptidomimetic residues into therapeutic peptides is highly efficacious and commonly employed, but generally requires laborious trial-and-error approaches. Previously, we demonstrated that C20 peptide has the potential to be a potential antiviral agent. Herein we report our attempt to improve the biological properties of this peptide by introducing peptidomimetics. Through combined alanine, proline, and sarcosine scans coupled with a competitive fluorescence polarization assay developed for identifying antiviral peptides, we enabled to pinpoint peptoid-tolerant peptide residues within C20 peptide. The synergistic benefits of combining these and other commonly employed methods could lead to a easily applicable strategy for designing and refining therapeutically-attractive peptidomimetics.

Autor: Minyoung Park, Modi Wetzler, Theodore S. Jardetzky, Annelise E. Barron

Fuente: http://plos.srce.hr/


Documentos relacionados