Protective Effect of Camellia sinensis on Methotrexate-Induced Small Intestinal Mucositis in MiceReportar como inadecuado




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Background: Green tea has been used as a daily beverage for severalyears. Anti-inflammatory effect of tea has also been depicted in differentpapers. Therefore we had set forward this study to examine the potential anti- inflammatory activity of green tea in small intestinemucositis experimental models. Aims: Evaluation of anti- inflammatory effects of green tea on mice. Materials andMethods: Green tea decoction 20% was prepared by soaking 20 g of green tea in 100 mlboiled water separately, soaked for 2 minutes and thereafter filtered. In- flammatory activity was induced using methotrexate 2.75 g-kg-24 h sc, and a protecting effect ofmucositis con- dition was investigated by vitamin E and Camellia sinensis decoction. StudyDesign: An experimental study was approved by an Animal Ethical Commitee. Results: Green tea decoction 20% has shownsignificant anti-in- flammatory effects 65%and 70% on methotrexate-induced acute mucositis model. In villous atrophyGreen tea decoction 10% and 20% has shown no protecting action at differentintestinal segments. But at intestinal crypt hyperplasia, green tea decoctionhas shown 65.74%, as compared to mucositis group. An increase of apoptoticbodies were acchieved at MTX group, CS reduced this occurrence. Conclusion:Taken together, our data indi- cate thatgreen tea 20% has a potential anti-inflammatory compared vitamin Eantioxidant action and cor- roborates withthe current trend of tea being promoted as -health drink-. However morepharmacological and biochemical assays is necessary to elucidate mechanisms.



KEYWORDS

Mucositis; Vitamin E; Camellia Sinensis; Morphometry; Mice; Cathechins

Cite this paper

Almeida, S. , Monteiro, M. , Lima, A. , Menezes, D. and Monteiro, S. 2014 Protective Effect of Camellia sinensis on Methotrexate-Induced Small Intestinal Mucositis in Mice. Food and Nutrition Sciences, 5, 443-448. doi: 10.4236-fns.2014.55052.





Autor: Samuel Brito de Almeida, Manuel Carlos Serra Azul Monteiro, Ana Valêska Pinto de Lima, Dalgimar Beserra de Menezes, Sandra Maria

Fuente: http://www.scirp.org/



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