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Delirium and itsrelation to biochemical markers have been considered a study question in several research works. The relation between S100Blevels and delirium is still a matter of discussion. Objective: To compare the serum level of S100B in patients withand without delirium and to detect the relation between S100B and deliriumsubtypes. Method: A case controlstudy was conducted on 114 elderly 60 years and older selected from thegeriatric acute care unit at Ain Shams University Hospitals. They were classifiedinto two groups; 58 elderly cases who had delirium diagnosed by ConfusionAssessment Method and 56 controls. Then delirium was reclassified accordingto the subtypes of delirium into Hyperactive: 46 patients, hypoactive: 2 patients,and Mixed: 10 patients. Serum S100B levels were determined by ELISA. Results: Cases were significantlyolder than controls 72.4 ± 9.4 versus 66.9 ± 5.3 years respectively P < 0.001.S100B levels were higher in cases 32.4 ± 9.8 pg-ml than controls 30 ± 9.3pg-ml but the difference was notstatistically significant P = 0.19. There was no significantdifference in S100B levels between the different subtypes of delirium. Conclusion: Delirious patients hadhigher S100B levels than controls but the difference was not statisticallysignificant.


Delirium; S100B; Elderly

Cite this paper

Aly, W. , Abdul-Rahman, S. , Said, S. and Bastawy, S. 2014 S100B and delirium in the geriatric acute care setting. Advances in Aging Research, 3, 1-5. doi: 10.4236-aar.2014.31001.

Autor: Walaa W. Aly, Samia A. Abdul-Rahman, Salma M. S. El Said, Samah A. Bastawy

Fuente: http://www.scirp.org/


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