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Purpose of thisstudy was to evaluate the variation of the dose to gross tumor volume GTVrelated to tumor position and lung density for lung stereotactic bodyradiotherapy SBRT using a virtual phantom. The density of the equivalent lungsurrounding the GTV 10 mm diameter was defined as 0.10, 0.15, 0.25, 0.35, and0.45 g-cm3. A planning target volume PTV was generated by adding auniform 8 mm margin to the internal target volume ITV. We defined that the99% of the GTV should be covered by 100% of the prescribed dose using MonteCarlo MC calculation. The GTV structure was replicated from ITV to the PTVperiphery at 1 mm intervals. Planned dose to the GTV was defined as thepredicted dose in the replicated GTV structure. Simulated dose to the GTV wasdefined as the calculated dose in the replicated GTV structure taking intoaccount the tumor position error. D99 of the planned dose to the GTV at the 8mm shift position was 78.1%, 81.6%, 87.3%, 91.4% and 94.4% at equivalent lung densities of 0.10,0.15, 0.25, 0.35, and 0.45 g-cm3, respectively. D99 of the simulateddose to the GTV at the 8 mm shiftposition was 96.9%, 95.3%,94.2%, 95.1 % and 96.3% at equivalent lung densities of 0.10, 0.15, 0.25, 0.35,and 0.45 g-cm3, respectively. Planned dose to GTV is stronglydependent on lung density and tumor position errors, while simulated dose to GTVdoes not show any significant dependence.

KEYWORDS

Lung Cancer; Stereotactic Body Radiotherapy; Tumor Position Error; Lung Density; Monte Carlo

Cite this paper

H. Miura, N. Masai, R. Oh, H. Shiomi, K. Yamada, M. Usmani and T. Inoue -Dosimetric Impact of Tumor Position and Lung Density Variations in Lung Stereotactic Body Radiotherapy,- International Journal of Medical Physics, Clinical Engineering and Radiation Oncology, Vol. 3 No. 1, 2014, pp. 43-48. doi: 10.4236-ijmpcero.2014.31007.





Autor: Hideharu Miura, Norihisa Masai, Ryoong-Jin Oh, Hiroya Shiomi, Kouichi Yamada, Muhammad Nauman Usmani, Toshihiko Inoue

Fuente: http://www.scirp.org/



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