Non-functioning Parathyroid Gland Carcinoma: Case ReportReportar como inadecuado

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Acta clinica Croatica, Vol.50 No.2 June 2011. -

Parathyroid gland carcinoma is a rare malignancy. The tumor is mostly functioning, causing severe hyperparathyroidism, with high serum calcium level and severe bone disease. Non-functioning parathyroid carcinomas are extremely rare. We report on a 60-year-old male patient admitted to ENT Department due to a large neck tumor mass compressing the thyroid and trachea. Preoperatively, thyroid hormone, parathyroid hormone PTH and calcium serum levels were normal. The following immunohistochemical markers DAKO, Denmark were used: bcl-2; CD- 10; Chromogranin-A; Cyclin-D1; EM A; Ki-67; Mdm-2; p-53; PGP-9,5; RCC; Synaptophysin; Thyroglobulin; and TTF -1. Immunohistochemical analysis indicated the diagnosis of a primary parathyroid gland carcinoma. Tumor cells showed diffusely positive immunohistochemical staining with chromogranin-A and PGP-9,5, positive staining of variable intensity with synaptophysin, and weakly positive reaction with EM A. Also, the cytoplasm of tumor cells was diffusely positively stained with bcl-2, while the nuclei showed positive reaction with p-53 oncogene and TTF -1. The remaining markers CD-10, cyclin-D1, Ki-67, Mdm-2, RCC and thyroglobulin were negative. Four years after the surgery, the patient died from renal carcinoma pulmonary metastases and liver cirrhosis complications. In conclusion, non-functioning parathyroid gland carcinoma is a very rare disease. Detailed immunohistochemical analysis is needed to distinguish it from other thyroid and parathyroid neoplasms and metastatic carcinoma. Surgical treatment is presently the best mode of therapy.

Parathyroid neoplasms – diagnosis; Parathyroid neoplasms – pathology; Non-functioning parathyroid neoplasms

Autor: Ana Krvavica - Marijan Kovačić - Ivan Baraka - Milan Rudić -



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