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Existing therapies for the treatment of chronic heartfailure still have some limitations and there is a pressing need for thedevelopment of new therapeutic modalities. The amniotic membrane has been usedfor the treatment of various diseases, such as conjunctive defects; however,the mechanisms behind its repair functions are still unclear. Regenerative medicineis seeking newer alternatives and among them, biomaterials have emerged inrecent years for developing and manipulating molecules, cells, tissues or organsgrown in laboratories in order to replace human body parts. Many such materialshave been used for this purpose, either synthetically or biologically, in orderto provide new medical devices. This review provides a wider view of theregeneration potential of the use of amniotic membrane as a potential biomaterialto facilitate the implementation of new research in surgical procedures.Amniotic membrane appears to be an alternative source of stem cells as well asan excellent biomaterial for cell-based therapeutic applications in engineeringheart tissue.

 

KEYWORDS

Amniotic Membrane; Heart; Tissue; Engineering; Stem Cells

Cite this paper

Francisco, J. , Cunha, R. , Simeoni, R. , Guarita-Souza, L. , Ferreira, R. , Irioda, A. , Souza, C. , Srikanth, G. , Nityanand, S. , Chachques, J. and de Carvalho, K. 2013 Amniotic membrane as a potent source of stem cells and a matrix for engineering heart tissue. Journal of Biomedical Science and Engineering, 6, 1178-1185. doi: 10.4236-jbise.2013.612147.





Autor: Julio Cesar Francisco, Ricardo Correa Cunha, Rossana Baggio Simeoni, Luiz Cesar Guarita-Souza, Reginaldo Justino Ferreira, Ana Ca

Fuente: http://www.scirp.org/



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