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Our previous studyshowed that prostaglandin J2 PGJ2 interacting factor PGJIF waspurified and identified with magnetic nanobeads. Farther analysis of PGJ2function shows that PGJ2 inhibits cell proliferation and rhodamine 123 incorporation. Using PGJ2- immobilizednanobeads, two targetproteins were also purified and identified as PGJIF1 and PGJIF2. PGJIF1 geneticanalysis showed that PGJIF1 regulatescell proliferation as well as rhodamine 123 incorporationin mitochondria, indicating that PGJIF1 is one of the PGJ2 target proteins. Theother target protein, PGJIF2, changes its intracellular localization inPGJ2-dependent manner. Using nanobeads technology,two PGJ2 target factors were purified and identified.

KEYWORDS

Prostaglandin J2; Nanobeads; Mitochondria

Cite this paper

Umeda, M. , Uebi, T. , Maekawa, N. , Handa, H. and Imai, T. 2013 PGJIFs, new mitochondrial PGJ2 target factors, regulate cell proliferation. Journal of Biosciences and Medicines, 1, 11-15. doi: 10.4236-jbm.2013.13003.





Autor: Makoto Umeda, Tatsuya Uebi, Naoya Maekawa, Hiroshi Handa, Takeshi Imai

Fuente: http://www.scirp.org/



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