Two Panels of Plasma MicroRNAs as Non-Invasive Biomarkers for Prediction of Recurrence in Resectable NSCLCReportar como inadecuado

Two Panels of Plasma MicroRNAs as Non-Invasive Biomarkers for Prediction of Recurrence in Resectable NSCLC - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

The diagnosis of non-small cell lung carcinoma NSCLC at an early stage, as well as better prediction of outcome remains clinically challenging due to the lack of specific and robust non-invasive markers. The discovery of microRNAs miRNAs, particularly those found in the bloodstream, has opened up new perspectives for tumor diagnosis and prognosis. The aim of our study was to determine whether expression profiles of specific miRNAs in plasma could accurately discriminate between NSCLC patients and controls, and whether they are able to predict the prognosis of resectable NSCLC patients. We therefore evaluated a series of seventeen NSCLC-related miRNAs by quantitative real-time qRT-PCR in plasma from 52 patients with I-IIIA stages NSCLC, 10 patients with chronic obstructive pulmonary disease COPD and 20-age, sex and smoking status-matched healthy individuals. We identified an eleven-plasma miRNA panel that could distinguish NSCLC patients from healthy subjects AUC = 0.879. A six-plasma miRNA panel was able to discriminate between NSCLC patients and COPD patients AUC = 0.944. Furthermore, we identified a three-miRNA plasma signature high miR-155-5p, high miR-223-3p, and low miR-126-3p that significantly associated with a higher risk for progression in adenocarcinoma patients. In addition, a three-miRNA plasma panel high miR-20a-5p, low miR-152-3p, and low miR-199a-5p significantly predicted survival of squamous cell carcinoma patients. In conclusion, we identified two plasma miRNA expression profiles that may be useful for predicting the outcome of patients with resectable NSCLC.

Autor: Céline Sanfiorenzo , Marius I. Ilie , Amine Belaid, Fabrice Barlési, Jérôme Mouroux, Charles-Hugo Marquette, Patrick Brest ,



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