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Wound infections can have devastating effects on healing as well asthe health of the patient. Complications increase when the pathogens arecapable of producing virulence factors and-or are drug resistant. Novel methodsare needed to take on the challenges of treating such wounds. Drawtex® dressing is purported to have hydroconductive properties that allow it to draw awaydebris and exudate from the wound into the dressing. The goal of this work isto better define these interactions of this experimental dressing with bacteriaand virulence factors. Two series of invitro experiments were performed. First, pieces of experimental dressingwere submerged in a series of cultures in flasks and samples of the dressingand cultures were taken over 90 minutes and assayed for bacteria and virulencefactor levels. Second, experimental or standard care control dressings wereplaced on selective agar plated with pathogens of interest. Dressings and theagar covered by them were used to quantify bacteria and virulence factors over time. Theexperimental dressing took up both bacteria and virulence factors to a largerextent than the control dressing. Experimental dressing significantly reducedthe load of bacteria and virulence factors in cultures compared to controlculture without dressing. Based on the ability of the dressing totake up bacteria and virulence factors in this study, the data point tothe potential for this dressing to be similarly effective in reducing or eliminatingpathogen from wounds, potentially increasing the chances of successfulwound healing.

KEYWORDS

Infection; MRSA; Virulence Factors; Dressing

Cite this paper

L. Moffatt, R. Ortiz, B. Carney, R. Bullock, M. Robson, M. Jordan and J. Shupp -In Vitro Mitigation of Pathogenic Bacteria and Virulence Factors Using a Hydroconductive Dressing,- Surgical Science, Vol. 4 No. 11, 2013, pp. 477-485. doi: 10.4236-ss.2013.411094.





Autor: Lauren T. Moffatt, Rachel T. Ortiz, Bonnie C. Carney, Rachael M. Bullock, Martin C. Robson, Marion H. Jordan, Jeffrey W. Shupp

Fuente: http://www.scirp.org/



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