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Background:In oral and maxillofacial surgery, synthetic bone grafts are most widely usedas bone substitutes, due to the limited sources of autologous bone. The aim ofthis study was to examine the influence of three different synthetic bone graftsCerasorb, Fortoss and Perioglass on sisters chromatide exchanges SCEs in peripherallymphocytes. Materials and Methods: Peripheral blood samples taken from 68 patients45 females and 23 males, who underwent oral surgery procedures, such as apicalresection, cyst enucleation or periodontal curretage, were obtained for SCE a daybefore and two months after the surgeries. A control group included 30 patients,while the study group was made of the patients who underwent bone grafting withCerasorb? 11 patients, Fortoss? VITAL 10 patients or Perioglass? 17 patients. Results: Comparing with the results of the study group before andafter the treatment, it was concluded that the results were statistically significantp = 0.001. In the Perioglass? subgroup, a greater statistical significance p = 0.003 was noted, than that in either the Cerasorb? p = 0.620or Fortoss? p = 0.210 subgroups, in which there was no statisticalsignificance. Conclusions: Although further investigations may be necessary, ourresults suggest that the synthetic bone grafts might have an influence on SCE inperipheral lymphocytes.

KEYWORDS

Bone Graft; Sisters Chromatide Exchange; Genotoxic; Bone Defect

Cite this paper

Köseoğlu, B. , Brkić, A. , Erdem, M. , Öztürk, Ş. , Palanduz, Ş. and Çefle, K. 2013 Is there a connection between synthetic bone grafts and sisters chromatide exchange?. Open Journal of Stomatology, 3, 447-451. doi: 10.4236-ojst.2013.38074.





Autor: Banu Gürkan Köseoğlu, Amila Brkić, Mehmet ali Erdem, Şükrü Öztürk, Şükrü Palanduz, Kivanç Çefle

Fuente: http://www.scirp.org/



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