A Case of Ectopic Growth Hormone Releasing Hormone GHRH from Pancreatic Neuroendocrine Tumor Resistant to TherapyReportar como inadecuado




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Introduction: Ectopicsecretion of GHRH is a rare cause of acromegaly. However, its recognition isclinically important because different therapeutic approaches are required. CasePresentation: We present a challenging case of acromegaly secondary toectopic GHRH secretion from pancreatic neuroendocrine tumor in a 52-year-oldfemale. The patient is treated with different modalities which includepegvisomant in an attempt to control the stimulated GH-axis considering thelimited data about its use in treatment of ectopic acromegaly. Conclusion: GHRH-secretingtumor is a rare cause of acromegaly. Surgical resection of the tumor is thetherapy of choice whenever possible. However, further studies are warranted forunresectable tumor or resistant cases.



KEYWORDS

Ectopic GHRH; Acromegaly; Pancreatic Neuroendocrine Tumor

Cite this paper

O. Almohareb and J. Rivera -A Case of Ectopic Growth Hormone Releasing Hormone GHRH from Pancreatic Neuroendocrine Tumor Resistant to Therapy,- Open Journal of Endocrine and Metabolic Diseases, Vol. 3 No. 7, 2013, pp. 271-275. doi: 10.4236-ojemd.2013.37037.





Autor: Ohoud Almohareb, Juan Rivera

Fuente: http://www.scirp.org/



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