Treatment of Malignant Liver Tumors by Radiofrequency Ablation Combined with Low-Frequency Ultrasound Radiation with MicrobubblesReportar como inadecuado




Treatment of Malignant Liver Tumors by Radiofrequency Ablation Combined with Low-Frequency Ultrasound Radiation with Microbubbles - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Objective

To explore the therapeutic efficacy and safety of malignant liver tumor treatment by radiofrequency ablation RA combined with low frequency ultrasound radiation with microbubbles LFURM.

Methods

Retrospective analysis of 25 patients with malignant hepatic tumors treated by RA-LFURM in the Department of Hepatobiliary Surgery of Kunming General Hospital affiliated to Chengdu Military District, PLA from January 2010 to June 2011. Ultrasound guided RA was performed, which was followed one week later by LFURM. Basal contrast ultrasound, liver function tests, and serum alpha fetoprotein AFP were obtained, and repeated 3 and 6 months after treatment. T-test and chi-square were used to compare parametric and non-parametric variables respectively.

Results

In 17 cases, gross tumor volume was significantly reduced 6 months after treatment while mean tumor showed a reduction of 50% compared to pre-treatment values. In 7 cases gross tumor volumes reduction was partial, but surrounding tumor tissue showed blood flow signals. One patient had no reduction in gross tumor volume. Levels of serum alanine aminotransferase ALT, aspartate aminotransferase AST, total bilirubin TBIL, alpha fetoprotein AFP decreased significantly 6 months after treatment all p<0.05. No tumor recurrence was seen during the 6 month follow-up. Quality of life scores QOL were good in 21 patients 84%, improved in 2 patients 8%, unchanged in 1 patient 4% and got worst in 1 patient 4%. Karnofsky scores KPS improved in 19 patients 76%, remained unchanged in 5 patients 2% and got worst in 1 patient 4%. Both QOL and KPS changes were statistically significant P<0.05.

Conclusion

RA-LFURM treatment of liver tumors is efficient and safe, and can reduce the gross tumor volumes and protect liver function.



Autor: Ai Junhua , Jin Yun , Wang Zhenzhou, Yang Ling, Luo Ding

Fuente: http://plos.srce.hr/



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