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Psychiatria Danubina, Vol.23. No.1. March 2011. -

Zolpidem is a non-benzodiazepine property which binds selectively to the α1-GABAA receptors, and has been widely prescribed

to patients suffering from insomnia. We report two cases of zolpidem dependence with withdrawal seizure in the Asian population.

The first case is a 43-year-old woman who took zolpidem up to the dosage of 200 to 400 mg per night. The second case is a 35-yearold

woman who even began to take zolpidem every 15 to 30 minutes to get euphoric and relaxed, and she gradually increased the

dosage to 400 to 500mg per day. After abrupt discontinuation of zolpidem, both cases immediately developed anxiety, global

insomnia, restlessness, and tonic seizure. The purpose of this case report is to suggest that clinicians should pay close attention to

the potential of zolpidem tolerance, abuse and dependence. The possibility of withdrawal seizure cannot be excluded especially at

high doses.

zolpidem; dependence; withdrawal; seizure

Autor: Liang-Jen Wang - ; Department of Psychiatry, Chang Gung Memorial Hospital at Keelung, Keelung, Taiwan Shao-Chun Ree - ; Departmen

Fuente: http://hrcak.srce.hr/


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