Biological activity of coumarin derivatives – a reviewReport as inadecuate

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Croatian journal of food science and technology, Vol.3 No.2 December 2011. -

Coumarin derivatives are wide spread in nature and found in many plants, fruits and vegetables. They show a broad spectrum of biological activities, but the use of coumarin is restricted by law and its maximal allowed concentration in foodstuff is determined by state regulations. As a model for investigation of coumarin toxicity rats have often been used, but some recent investigations indicate that the coumarin metabolism and therefore coumarin toxicity, are much different in humans and rats. This paper sums up coumarin biological properties as well as specificity of coumarin metabolism in rats and humans.

coumarin; metabolism; biological activity; toxicity

Author: Maja Molnar - ; University of Josip Juraj Strossmayer in Osijek, Faculty of Food Technology Osijek, Franje Kuhača 20, 31000 Osij



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