Antitumor Effects of Conditional Replication Adenovirus in Combination with Cisplatin on Lung CancerReportar como inadecuado




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Object:To explore the therapeutic effects and therapeutic mechanisms of ConditionalReplication AdenovirusCRAd in combination with cisplatin on lung cancercells. Methods: Using MTS - PMS assay, invitro cell inhibition assay was performed to detect the cell viability oftwo lung cancer cell lines, NCI-H292 and NCI-H661. PCR was employed to detectthe Coxsackie receptorCAR expression of cancer cells. The in vivo anti-tumor effect of CRAd andcisplatin was evaluated using a subcutaneous mouse model. Results: The CRAdwith cisplatin is superior to the use of cisplatin or CRAd viruse alone on thesuppression of lung cancer cell growth. The mechanism of inhibition isassociated with the increased CAR expression. Conclusion: The application ofCRAd in combination with cisplatin could play a better therapeutic effect onlung cancer cell growth inhibition.

KEYWORDS

Lung Cancer; Adenovirus; Cisplatin

Cite this paper

Y. Liu and Y. Huang -Antitumor Effects of Conditional Replication Adenovirus in Combination with Cisplatin on Lung Cancer,- Engineering, Vol. 4 No. 10B, 2012, pp. 163-164. doi: 10.4236-eng.2012.410B042.





Autor: Yanan Liu, Yinghui Huang

Fuente: http://www.scirp.org/



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