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Objective: Acute kidney injury in major surgery is associated with increased postoperativemortality. This study aimed to evaluate renal function after major urologicsurgery and intraoperative dexmedetomidine infusion. Methods: Thirty oncologic patients with normal renal functionscheduled for prostatectomy or nephrectomy, anesthetized with combined epiduraland general anesthesia, were randomized to receive either intraoperative blindinfusion of dexmedetomidine Dexmedetomidine Group, n = 15, 0.5 μg-kg load dose plus 0.7 μg-kg-hor 0.9% saline Control Group, n = 15 until the endof surgery. Intraoperative and cumulative 24-hour diuresis, serum creatinine SCr,calculated creatinine clearance ClCr and serum cystatin C SCysat postoperative days 1, 2 and 3 and 2 weeks after surgery were evaluated. Results: Mean ± standard deviation values for intraoperativediuresis in Dexmedetomidine and Control Groups were 566 ± 396 mL and 298 ± 153 mL, respectively p = 0.014. Cumulative 24-hour diuresis inDexmedetomidine and Control Groups was 1947 ± 266 mL and 1748 ± 237 mL,respectively p = 0.91. Mean values of SCr, ClCr and SCys were not significantly different from their baseline values in both groups and no significantdifferences were seen between groups at any moment for two weeks p > 0.05. Conclusion: According to the dosesused in this study, despite an intraoperative increase in diuresis,intraoperative infusion of dexmedetomidine did not influence renal performanceup to two weeks after major uro-oncologic surgery, as evaluated by SCr,ClCr and SCys.


Dexmedetomidine; Renal Function; Nephrectomy; Prostatectomy; Epidural; General Anesthesia

Cite this paper

M. M. Novaes, P. G. Lavinas, G. D. Pires, A. G. de Carvalho, R. B. Lopes, R. El Dib and P. Nascimento Jr. -Renal Function after Major Uro-Oncologic Surgery and Dexmedetomidine Infusion,- Open Journal of Anesthesiology, Vol. 3 No. 8, 2013, pp. 356-362. doi: 10.4236-ojanes.2013.38076.

Autor: Marcus Vinicius M. Novaes1, Paulo Sergio G. Lavinas1, Grace Haber D. Pires1, Ana Claudia G. de Carvalho1, Renata M. B. Lopes1, Re



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