High Spatial Resolution and Temporally Resolved T2* Mapping of Normal Human Myocardium at 7.0 Tesla: An Ultrahigh Field Magnetic Resonance Feasibility StudyReportar como inadecuado




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Myocardial tissue characterization using T2* relaxation mapping techniques is an emerging application of preclinical cardiovascular magnetic resonance imaging. The increase in microscopic susceptibility at higher magnetic field strengths renders myocardial T2* mapping at ultrahigh magnetic fields conceptually appealing. This work demonstrates the feasibility of myocardial T2* imaging at 7.0 T and examines the applicability of temporally-resolved and high spatial resolution myocardial T2* mapping. In phantom experiments single cardiac phase and dynamic CINE gradient echo imaging techniques provided similar T2* maps. In vivo studies showed that the peak-to-peak B0 difference following volume selective shimming was reduced to approximately 80 Hz for the four chamber view and mid-ventricular short axis view of the heart and to 65 Hz for the left ventricle. No severe susceptibility artifacts were detected in the septum and in the lateral wall for T2* weighting ranging from TE = 2.04 ms to TE = 10.2 ms. For TE >7 ms, a susceptibility weighting induced signal void was observed within the anterior and inferior myocardial segments. The longest T2* values were found for anterior T2* = 14.0 ms, anteroseptal T2* = 17.2 ms and inferoseptal T2* = 16.5 ms myocardial segments. Shorter T2* values were observed for inferior T2* = 10.6 ms and inferolateral T2* = 11.4 ms segments. A significant difference p = 0.002 in T2* values was observed between end-diastole and end-systole with T2* changes of up to approximately 27% over the cardiac cycle which were pronounced in the septum. To conclude, these results underscore the challenges of myocardial T2* mapping at 7.0 T but demonstrate that these issues can be offset by using tailored shimming techniques and dedicated acquisition schemes.



Autor: Fabian Hezel, Christof Thalhammer, Sonia Waiczies, Jeanette Schulz-Menger, Thoralf Niendorf

Fuente: http://plos.srce.hr/



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