Neonatal Plasmacytoid Dendritic Cells pDCs Display Subset Variation but Can Elicit Potent Anti-Viral Innate ResponsesReportar como inadecuado




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Neonates are highly susceptible to infectious diseases and defective antiviral pDC immune responses have been proposed to contribute to this phenomenon. Isolated cord blood pDCs innately responded to a variety of TLR7 and TLR9 dependent viruses, including influenza A virus IAV, human immunodeficiency virus HIV or herpes-simplex virus HSV by efficiently producing IFN-α, TNF-α as well as chemokines. Interestingly, following activation by CpGA, but not viruses, cord pDCs tend to survive less efficiently. We found that a hallmark of pDCs in neonates is an extended CD2+pDCs compartment compared to adult pDCs without affecting the antiviral IFN-α response. Within CD2+pDCs, we identified a subpopulation expressing CD5 and responsible for IL-12p40 production, however this population is significantly decreased in cord blood compared to adult blood. Therefore, neonatal pDCs clearly display variation in phenotype and subset composition, but without major consequences for their antiviral responses.



Autor: Xiaoming Zhang, Alice Lepelley, Elie Azria, Pierre Lebon, Gwenaelle Roguet, Olivier Schwartz, Odile Launay, Claude Leclerc, Richa

Fuente: http://plos.srce.hr/



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