Does GSTP1 Polymorphism Contribute to Genetic Damage Caused by Ageing and Occupational ExposureReportar como inadecuado




Does GSTP1 Polymorphism Contribute to Genetic Damage Caused by Ageing and Occupational Exposure - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Archives of Industrial Hygiene and Toxicology, Vol.62 No.4 December 2011. -

The aim of our study was to see the effects of GSTP1 polymorphism on biomarkers of ageing, including micronuclei MN, comet tail length, and relative telomere length in automobile repair workers, who are exposed to a broad spectrum of potential mutagens. The analysis was performed on buccal cells collected from occupationally exposed and non-exposed control subjects. Samples were analysed using cytogenetic and molecular methods, including restriction fragment length polymorphism RFLP, MN test, comet assay, and real-time PCR. The results confi rmed the DNA damaging effects of substances used in the mechanical workshops, but did not confirm the infl uence of GSTP1 gene polymorphism on DNA damage. However, further studies on both occupationally exposed and control populations are needed to understand the relationship between GSTP1 polymorphism and genome damage.

buccal cells; comet tail length; glutathione S-transferases; micronucleus frequency; PCR; RFLP; telomere length



Autor: Sima Ataollahi Eshkoor - ; Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, UPM Serdang, Selangor, Malaysia Pa

Fuente: http://hrcak.srce.hr/



DESCARGAR PDF




Documentos relacionados