Histone Demethylase Jumonji D3 JMJD3 as a Tumor Suppressor by Regulating p53 Protein Nuclear StabilizationReportar como inadecuado




Histone Demethylase Jumonji D3 JMJD3 as a Tumor Suppressor by Regulating p53 Protein Nuclear Stabilization - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Histone methylation regulates normal stem cell fate decisions through a coordinated interplay between histone methyltransferases and demethylases at lineage specific genes. Malignant transformation is associated with aberrant accumulation of repressive histone modifications, such as polycomb mediated histone 3 lysine 27 H3K27me3 resulting in a histone methylation mediated block to differentiation. The relevance, however, of histone demethylases in cancer remains less clear. We report that JMJD3, a H3K27me3 demethylase, is induced during differentiation of glioblastoma stem cells GSCs, where it promotes a differentiation-like phenotype via chromatin dependent INK4A-ARF locus activation and chromatin independent nuclear p53 protein stabilization mechanisms. Our findings indicate that deregulation of JMJD3 may contribute to gliomagenesis via inhibition of the p53 pathway resulting in a block to terminal differentiation.



Autor: Chibawanye I. Ene, Lincoln Edwards, Gregory Riddick, Mehmet Baysan, Kevin Woolard, Svetlana Kotliarova, Chen Lai, Galina Belova,

Fuente: http://plos.srce.hr/



DESCARGAR PDF




Documentos relacionados