Adenoid Cystic Carcinoma of the Head and Neck: Epidemiology and Predictors of PrognosisReport as inadecuate

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Objectives: The biologic behavior of the adenoid cystic carcinoma ACC and the factors predicting outcome for these tumors are still poorly understood. Our objective is to analyze the predicting factors and the value of different treatment possibilities, since none sole treatment has been standardized. Methods: A retrospective analysis of the epidemiologic, clinical and histologic aspects of ACC, as well as treatment options and other prognostic factors of all the cases of ACC of the head and neck treated at this Institution were analyzed. From 1974 until 2011, 152 patients were diagnosed with ACC and treated at the Portuguese Institute of Oncology Porto Centre. Main outcome measures: overall survival, local recurrence and distant metastasis were calculated by the Kaplan-Meier method. Factors predictive of outcome were identified by univariate and multivariate analysis. Results: The mean age at diagnosis was 55.8 years range, 19-83 years. Incidence was higher in the female population, with a female to male ratio of 1.7:1 respectively. The primary tumor location was hard palate and submandibular region in 56 cases, 28 in each location 24.6%, parotid gland 17 cases, 14.9% and oral cavity excluding palate 16 cases, 14%.Distributions according to T stage were: T1 29.8%; T2 30.7%; T3 17.5%; T4 22%. The overall 1-year, 5-year and 10-year survival for all patients were 94.6%, 60.5%, 41.6%, respectively. Conclusions: Univariate survival analysis revealed that age older than 60 years p = 0.002, solid histologic subtype p = 0.042, advanced clinical stage p < 0.001 and the presence of perineural invasion p = 0.036 were correlated with a poor survival. Multivariate analysis confirmed that age and advanced clinical stage were worst independent predicators of overall survival as well as perineural invasion for local recurrence and distant metastasis. In our analysis, radiotherapy did not have a relevant impact on survival, except in cases of solid histologic subtype. To analyze distant metastatic capacity, long term follow-up was necessary, since distant metastasis way occurs even after 10 years, which has the case with 4 patients.


Adenoid Cystic Carcinoma; Head and Neck Cancer; Prognostic Factors

Cite this paper

D. Monteiro, J. Lino, T. Bernardo, J. Fernandes and E. Monteiro -Adenoid Cystic Carcinoma of the Head and Neck: Epidemiology and Predictors of Prognosis,- International Journal of Otolaryngology and Head & Neck Surgery, Vol. 2 No. 5, 2013, pp. 165-173. doi: 10.4236-ijohns.2013.25036.

Author: Daniel Monteiro, João Lino, Teresa Bernardo, João Fernandes, Eurico Monteiro



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