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Croatian medical journal, Vol.52 No.5 October 2011. -

Aim To assess iodine supply and follow thyroid epidemiology

for ten years after an iodine increase from 10 to 25 mg

of potassium iodide per kilogram of salt in 1999.

Methods In 2002 and 2003, we determined the thyroid

size by palpation and ultrasound and measured urinary

iodine concentration UIC in 676 schoolchildren from 34

schools throughout Slovenia. From 1999 to 2009, we followed

the incidence of diffuse and nodular goiter, thyroid

autonomy, Graves’ disease, and Hashimoto’s thyroiditis

among adults in the stable catchment area of the University

Medical Centre Ljubljana with 1 000 000 inhabitants.

Results In children, only 1% had a goiter grade 2 visible

and palpable thyroid gland, median thyroid volume was

5.8 mL, and median UIC was 148 μg-L. In adults, the incidence

of diffuse goiter and thyroid autonomy decreased

significantly 2009 vs 1999, rate ratio RR, 0.16; 95% confidence

interval CI, 0.12-0.21 and RR, 0.73; 95% CI, 0.62-

0.86, respectively, with a lower incidence in younger participants

in 2009 P < 0.001. The incidence of multinodular

goiter and solitary nodule increased 2009 vs 1999, RR, 1.55;

95% CI, 1.35-1.79 and RR, 1.72; 95% CI, 1.49-1.99, respectively.

No long-term changes were observed for Graves’ disease

2009 vs 1999, RR, 0.95; 95% CI, 0.81-1.13, while the incidence

of Hashimoto’s thyroiditis increased strongly 2009

vs 1999, RR, 1.86; 95% CI, 1.64-2.12.

Conclusions The change from mildly deficient to sufficient

iodine supply was associated with a marked change

in the incidence of thyroid epidemiology – a significant decline

in the incidence of diffuse goiter and thyroid autonomy

and a marked increase in the incidence of Hashimoto’s

thyroiditis.

iodine supply; thyroid epidemiology; Slovenia; goiter; thyroid autonomy; Graves’ disease; Hashimoto’s thyroiditis



Autor: Katja Zaletel - ; Department of Nuclear Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia Simona Gaberšček - ;

Fuente: http://hrcak.srce.hr/



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