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Croatian medical journal, Vol.52 No.5 October 2011. -

Aim To analyze potential and actual drug-drug interactions

reported to the Spontaneous Reporting Database of

the Croatian Agency for Medicinal Products and Medical

Devices HALMED and determine their incidence.

Methods In this retrospective observational study performed

from March 2005 to December 2008, we detected

potential and actual drug-drug interactions using interaction

programs and analyzed them.

Results HALMED received 1209 reports involving at least

two drugs. There were 468 38.7% reports on potential

drug-drug interactions, 94 of which 7.8% of total reports

were actual drug-drug interactions. Among actual drugdrug

interaction reports, the proportion of serious adverse

drug reactions 53 out of 94 and the number of drugs

n = 4 was significantly higher P < 0.001 than among the

remaining reports 580 out of 1982; n = 2, respectively. Actual

drug-drug interactions most frequently involved nervous

system agents 34.0%, and interactions caused by

antiplatelet, anticoagulant, and non-steroidal anti-inflammatory

drugs were in most cases serious. In only 12 out of

94 reports, actual drug-drug interactions were recognized

by the reporter.

Conclusion The study confirmed that the Spontaneous

Reporting Database was a valuable resource for detecting

actual drug-drug interactions. Also, it identified drugs leading

to serious adverse drug reactions and deaths, thus indicating

the areas which should be in the focus of health

care education

Systems; anticoagulants, antiplatelet drugs; anti-Inflammatory agents; non-steroidal; central vervous system drugs; peripheral nervous system drugs



Autor: Nikica Mirošević Skvrce - orcid.org-0000-0002-3222-0345 ; Pharmacovigilance Department Agency for Medicinal Products and Medica

Fuente: http://hrcak.srce.hr/



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