Evaluation of CDK6 and p16-INK4a-Derived Peptides InteractionReport as inadecuate

Evaluation of CDK6 and p16-INK4a-Derived Peptides Interaction - Download this document for free, or read online. Document in PDF available to download.

 The goal of this work is the development of novel peptides with high efficacy of inhibiting activity of CDK6-CyclinD complex. The peptides were derived from primary sequence of P16 protein and its homologues. The interactions between CDK6 and P16-INK4a-derived peptides are studied with molecular dynamics simulation employing umbrella sampling method. The SASA implicit solvent model was used for simulation, which was accelerated using NVIDIA GPUs.


Cyclin-Dependent Kinases; Molecular Dynamics; Umbrella Sampling; GPU; SASA

Cite this paper

Kazennov, A. , Alekseenko, A. , Bozhenko, V. , Kulinich, T. , Shuvalov, N. and Kholodov, Y. 2013 Evaluation of CDK6 and p16-INK4a-Derived Peptides Interaction. Computational Molecular Bioscience, 3, 53-57. doi: 10.4236-cmb.2013.33007.

Author: Andrey Kazennov, Andrey Alekseenko, Vladimir Bozhenko, Tatiana Kulinich, Nikolay Shuvalov, Yaroslav Kholodov

Source: http://www.scirp.org/


Related documents