Aqueous Extract of Saffron Crocus sativus Increases Brain Dopamine and Glutamate Concentrations in RatsReportar como inadecuado




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Recent studies involving human and animal models have identified that saffron helps in the improvement of depression. Antidepressants are known to function in part by increasing brain serotonin, norepinephrine and dopamine concentrations. Therefore, to identify the cellular and molecular mechanisms underlying this property of saffron, we measured changes in rat brain dopamine, serotonin, norepinephrine and glutamate concentrations after administration of varying doses of an aqueous extract of saffron stigma. Male Wistar rats 250 ± 30 g were administered a single dose of saffron extract 5, 25, 50, 100, 150, and 250 mg-kg, i.p., fluoxetine 10 mg-kg, i.p., and-or desipramine 50 mg-kg, i.p. and were sacrificed 30 min later. Brains were removed, homogenized, and centrifuged at 4?C. The supernatant was used for subsequent neurotransmitter detection by ELISA. Our results indicated that the aqueous extract of saffron 50, 100, 150 and 250 mg-kg, i.p. increased brain dopamine concentration in a dose-dependent manner compared with saline. In addition, the brain glutamate concentration increased in response to the highest dose of the extract 250 mg-kg, i.p

Interestingly, the extract had no effect on brain serotonin or norepinephrine concentration. Our findings show that the aqueous extract of saffron contains an active component that can trigger production of important neurotransmitters in brain, namely, dopamine and glutamate. In addition, these results provide a cellular basis for reports concerning the antidepressant properties of saffron extract in humans and animals.

KEYWORDS

Saffron; Glutamate; Dopamine; Norepinepherine; Serotonin

Cite this paper

H. Ettehadi, S. Mojabi, M. Ranjbaran, J. Shams, H. Sahraei, M. Hedayati and F. Asefi -Aqueous Extract of Saffron Crocus sativus Increases Brain Dopamine and Glutamate Concentrations in Rats,- Journal of Behavioral and Brain Science, Vol. 3 No. 3, 2013, pp. 315-319. doi: 10.4236-jbbs.2013.33031.





Autor: Hosseinali Ettehadi, Seyedeh Nargesolsadat Mojabi, Mina Ranjbaran, Jamal Shams, Hedayat Sahraei, Mahdi Hedayati, Farzad Asefi

Fuente: http://www.scirp.org/



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